Functional health consulting for immune & inflammatory support in Knoxville, TN

At Main Health Collective, we take a whole-body, individualized approach to support immune & inflammatory conditions .

Whether your goal is to better understand your immune system, support resilience during times of increased stress, or gain clarity around ongoing inflammatory patterns, our immune and inflammatory support is built around you. We focus on education, lifestyle guidance, and root-cause conversations to help you feel more empowered in your health decisions. Schedule a free discovery call with Dr. Marissa to see if this style of functional health consulting is the right fit for what you’re experiencing or looking for.

Immune & Inflammatory Conditions

  • Autoimmune conditions

  • Frequent colds or feeling run down

  • Allergies/Food sensitivities

  • Recurrent congestion

  • Chronic low grade inflammation patterns

  • Chronic rashes

Please recognize that this list is not exhaustive of every condition we are able to support with functional health consulting.

Assorted fresh vegetables and fruits including sliced cucumbers, raspberries, sliced mushrooms, shredded cheddar cheese, cherry tomatoes, strawberries, and broccoli.

Our Approach to Immune & Inflammatory Support


We begin with a comprehensive, root-cause–informed conversation focused on immune and inflammatory patterns. This may include exploring how often you get sick, how your body recovers, energy levels, stress exposure, digestion, sleep, and environmental influences. We look for patterns and contributing factors that may be influencing immune resilience and inflammatory balance.

1. Assess the Root-Cause


2. Support the Body’s Natural Balance

Our approach focuses on supporting the body’s innate ability to adapt and regulate. Instead of targeting symptoms directly, we emphasize foundational lifestyle and nutrition guidance designed to reduce unnecessary stress on the system and support overall balance. Recommendations may include guidance around food choices, daily rhythms, stress support, and the thoughtful use of supplements, herbal remedies, and homeopathic remedies when appropriate.


3. Build Strong, Sustainable Foundations

Many health concerns are interconnected, which is why we prioritize foundational habits that support the whole body. This phase focuses on consistency and sustainability, helping you implement realistic changes that can be maintained long-term.
Education plays a central role, empowering you with a deeper understanding of your body and how everyday choices influence overall well-being.


4. Reclaim Confidence in your Health

Our goal is not short-term symptom management, but long-term confidence and autonomy in your health. Through ongoing education and support, we help you build skills and awareness that apply across changing health goals and life stages.
This approach allows you to feel informed, supported, and capable of caring for your body over time—no matter the condition or focus area.


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It’s important to note that no two individuals are the same. That’s why every care plan is tailored to the individual. At Main Health Collective, our functional health consulting focuses on education, lifestyle support, and individualized guidance to help you feel supported, informed, and confident in your health.

  • “I was a patient of Dr. Marissa for nearly two years, and she was my very first naturopathic doctor. From the beginning, working with Dr. Marissa transformed my life. She embodies compassion. She cared so deeply and genuinely about my medical concerns, and from day one treated me as though she truly knew me. Over time, our doctor-patient relationship grew into a space of deep trust and I felt safe bringing her everything including my frustrations, my fears, my health struggles. I felt this way because I knew that I would be met with honesty, warmth, and unwavering care and support. On a consistent basis, she went above and beyond to ensure that I felt comfortable, heard, and supported.”

    - Trinity

  • “I showed up with a back injury that was incredibly painful and limiting. Within the first couple sessions I had significant relief. Dr. (Zach) Main took time to clearly explain what was going on and how we would treat it. His focus was on both treating the injury but also ensuring that I had a plan in place to prevent it from recurring.”

    - Brad

  • “Absolutely love Dr. Marissa! She has explained so much to me on one visit than all my doctors combined in several years! She was able to tell me things from reading my bloodwork that my doctors did not even pick up. Honestly amazing! She is so sweet, really listens and like I said really explains things! I highly recommend her!"

    - Angela

  • “Dr. (Zach) Main made me feel at ease from the start. He is very patient when teaching exercises and is thorough when explaining the course of treatment. My lower back pain had significantly reduced with his help. Highly recommend!”

    - Yamina